Heart Rhythm Partners

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Pyrophosphate (PYP) Scan

Advanced imaging to detect cardiac amyloidosis early.

A Pyrophosphate (PYP) Scan is a specialized nuclear imaging test used to diagnose a rare but serious condition called transthyretin cardiac amyloidosis (ATTR-CM)—a form of heart failure caused by the buildup of abnormal proteins (amyloid) in the heart tissue. ATTR-CM can be difficult to detect using standard imaging, but the PYP scan offers a non-invasive, highly sensitive method for identifying this disease early and accurately.

 

At Heart Rhythm Partners, we use PYP scanning as part of our advanced diagnostic pathway for patients with unexplained heart failure, thickened heart walls, or suspected amyloidosis, especially in older adults or those with family history of the condition.

 

What We Offer in PYP Scanning:

  • Non-invasive nuclear imaging using a small amount of radioactive tracer.
  • Performed in partnership with certified nuclear medicine centers.
  • High-resolution detection of ATTR-related amyloid deposits in the heart.
  • Used to differentiate between transthyretin (ATTR) and light chain (AL) amyloidosis.
  • Supports diagnosis without the need for heart biopsy in many cases.
  • Coordinated evaluation with cardiac MRI, echocardiography, and blood work.
  • Comprehensive care planning with heart failure and genetics specialists.
  • Helps guide eligibility for targeted therapies and clinical trials.

Early Diagnosis

Detect amyloidosis before it causes irreversible heart damage.

01

Non-Invasive & Accurate

Avoid biopsy with a simple, effective nuclear scan.

02

Targeted Treatment

Supports early access to therapies specifically for ATTR-CM.

03

Why It Matters:

ATTR cardiac amyloidosis is often misdiagnosed as hypertensive heart disease or other forms of cardiomyopathy, delaying the correct treatment. A PYP scan can help provide clarity—allowing for an early diagnosis and access to emerging treatments that slow disease progression and improve quality of life. It’s especially valuable for men over 60 with unexplained heart failure or people of African or Afro-Caribbean descent, where hereditary forms may be more common.